Key Publications

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Stromal biology and therapy in pancreatic cancer

Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Publications

Precision Medicine in Pancreatic Cancer: Targeting KRAS and Beyond

Targeting of MEK and Autophagy in Pancreatic Adenocarcinoma and Analysis of Treatment Sensitivity in Preclinical and Clinical Models: MEKiAUTO

Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1

Electroporation-Induced Gastric Cancer Models Through Epithelial-Specific Genetic Modifications

The very druggable RAS proteins

Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma

Pancreatic Cancer–Associated Fibroblasts: Where Do We Go from Here?

Addressing Biological Questions with Preclinical Cancer Imaging

Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression

An NFATc1/SMAD3/cJUN Complex Restricted to SMAD4-Deficient Pancreatic Cancer Guides Rational Therapies

Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts

Generation and ex vivo culture of murine and human pancreatic ductal adenocarcinoma tissue slice explants

Transfusion of salvaged red blood cells during pancreatic ductal adenocarcinoma operations

A transcriptome-based precision oncology platform for patient-therapy alignment in a diverse set of treatment resistant malignancies

Comprehensive DNA methylation analysis indicates that pancreatic intraepithelial neoplasia lesions are acinar-derived and epigenetically primed for carcinogenesis

Specific regulation of BACH1 by the hotspot mutant p53R175H reveals a distinct gain-of-function mechanism

Pervasiveness of HLA allele-specific expression loss across tumor types

Pharmacological targeting of the receptor ALK inhibits tumorigenicity and overcomes chemoresistance in pancreatic ductal adenocarcinoma

Generation of orthotopic patient-derived xenograft models for pancreatic cancer using tumor slices

Harmonic Motion Imaging of Pancreatic Tumor Stiffness Indicates Disease State and Treatment Response

Effective delivery of a microtubule polymerization inhibitor synergizes with standard regimens in models of pancreatic ductal adenocarcinoma

Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes

Laser Capture Microdissection on Frozen Sections for Extraction of High-Quality Nucleic Acids

Comprehensive characterisation of compartmentspecific long non-coding RNAs associated with pancreatic ductal adenocarcinoma

Elasticity mapping of murine abdominal organs in vivo using Harmonic Motion Imaging (HMI)

Translational Therapeutics in Genetically Engineered Mouse Models of Cancer

Acquisition of Mouse Tumor Biopsies through Abdominal Laparotomy

Identification and Manipulation of Biliary Metaplasia in Pancreatic Tumors

Pancreatic cancer: why is it so hard to treat?

Recapitulating human cancer in a mouse

Quantification of Murine Pancreatic Tumors by High Resolution Ultrasound

Genetically Engineered Mouse Models of Pancreatic Cancer

Silencing the Killers: Paracrine Immune Suppression in Pancreatic Cancer

A novel method for quantiWcation of gemcitabine and its metabolites 2,2-diXuorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC–MS/MS: comparison with 19F NMR spectroscopy

Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer

Heterozygosity for Hypoxia Inducible Factor 1α decreases the incidence of thymic lymphomas in a p53 mutant mouse model

K-Ras-Driven Pancreatic Cancer Mouse Model for Anticancer Inhibitor Analyses

The Use of Targeted Mouse Models for Preclinical Testing of Novel Cancer Therapeutics

The Differential Effects of Mutant p53 Alleles on Advanced Murine Lung Cancer

Mice Expressing a Mammary Gland-Specific R270H Mutation in the p53 Tumor Suppressor Gene Mimic Human Breast Cancer Development